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Biology what is substrate, L transporter & Amino Acids question?

I need someone (who understands biology) to explain the paragraph below in laymans terms. with regard to what it could mean in Human pregnancy, if the same were to happen as in mice and rats etc. i.e how important are the large amino acids, what is their job, what is an L transporter and is the paragraph below saying that it's job is inhibited by the drug. Is it a good thing that it doesn't bind to plasma proteins? "Pregabalin does not bind to plasma proteins. The apparent volume of distribution of pregabalin following oral administration is approximately 0.5 L/kg. Pregabalin is a substrate for system L transporter which is responsible for the transport of large amino acids across the blood brain barrier. Although there are no data in humans, pregabalin has been shown to cross the blood brain barrier in mice, rats, and monkeys" If someone could put an explanation after each sentance that would be great, i know it's a lot to ask but I ask the question for personal reasons which I am sure you can draw your own conclusions from. Thank you very much.

Public Comments

1. "Pregabalin does not bind to plasma proteins.(This is good because it means that when it is given to the subject, all of it is available for transport into brain, and none is bound to serum proteins). The apparent volume of distribution of pregabalin following oral administration is approximately 0.5 L/kg.(This by itself doesn't tell us alot, unless we compare it to other drugs and their distribution). Pregabalin is a substrate for system L transporter which is responsible for the transport of large amino acids across the blood brain barrier.(This is good and bad. It is good because that means it gets into the brain. It is bad because this means it will compete with other amino acids for access to the brain, so depending on what amino acids are in the diet, this drug may or may not enter the brain). Although there are no data in humans, pregabalin has been shown to cross the blood brain barrier in mice, rats, and monkeys"(This is good if you want it to work in the central nervous system. This is bad if you don't want it to work in the central nervous system.)